مقاله The Selective Cyclooxygenase-2 Inhibitor, the Compound 11b Improves Haloperidol Induced Catatonia by Enhancing the Striatum Dopaminergic Neurotransmission

مقاله The Selective Cyclooxygenase-2 Inhibitor, the Compound 11b 
Improves Haloperidol Induced Catatonia by Enhancing the Striatum 
Dopaminergic Neurotransmission

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مقاله The Selective Cyclooxygenase-2 Inhibitor, the Compound 11b
Improves Haloperidol Induced Catatonia by Enhancing the Striatum
Dopaminergic Neurotransmission دارای 9 صفحه می باشد و دارای تنظیمات در microsoft word می باشد و آماده پرینت یا چاپ است

فایل ورد مقاله The Selective Cyclooxygenase-2 Inhibitor, the Compound 11b
Improves Haloperidol Induced Catatonia by Enhancing the Striatum
Dopaminergic Neurotransmission کاملا فرمت بندی و تنظیم شده در استاندارد دانشگاه و مراکز دولتی می باشد.

توجه : در صورت  مشاهده  بهم ريختگي احتمالي در متون زير ،دليل ان کپي کردن اين مطالب از داخل فایل ورد مي باشد و در فايل اصلي مقاله The Selective Cyclooxygenase-2 Inhibitor, the Compound 11b
Improves Haloperidol Induced Catatonia by Enhancing the Striatum
Dopaminergic Neurotransmission،به هيچ وجه بهم ريختگي وجود ندارد


بخشی از متن مقاله The Selective Cyclooxygenase-2 Inhibitor, the Compound 11b
Improves Haloperidol Induced Catatonia by Enhancing the Striatum
Dopaminergic Neurotransmission :

سال انتشار : 2010

تعداد صفحات : 9

A substantial amount of evidence has proposed an important role for Cyclooxygenase-2 (COX-2) enzyme in brain diseases and affiliate disorders. The purpose of this research was studying the effects of COX-2 selective inhibition on haloperidol-induced catatonia in an animal model of drug overdose and Parkinson’s disease (PD). In this study, the effect of acute and Sub-chronic oral administration of a new selective COX-2 inhibitor, i.e. the compound 11b or 1-(Phenyl)-5-(4-methylsulfonylphenyl)-2-ethylthioimidazole, in a dosage of 2, 4 and 8 mg/kg on haloperidol-induced catatonia was evaluated and compared to the standard drug scopolamine (1 mg/kg) by microanalysis of Striatum dopaminergic neurotransmission. The results showed a very high potency for 11b in improving the catalepsy by enhancing the dopaminergic neurotranmission (p < 0.05). In addition, statistical analysis showed the dose- and time-dependent behavior of the observed protective effect of 11b against the haloperidol-induced catatonia and enhancement of the dopaminergic neurotransmission. These findings are additional pharmacological data that suggest the effectiveness of COX-2 inhibition in treatment of schizophreny-associated rigidity.

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Improves Haloperidol Induced Catatonia by Enhancing the Striatum
Dopaminergic Neurotransmission آماده ارائه به شما پژوهنده عزیز میباشد.با کلیک روی دکمه ادامه مطلب به صفحه توضیحات کامل مقاله The Selective Cyclooxygenase-2 Inhibitor, the Compound 11b
Improves Haloperidol Induced Catatonia by Enhancing the Striatum
Dopaminergic Neurotransmission هدایت میشوید
مقاله The Selective Cyclooxygenase-2 Inhibitor, the Compound 11b
Improves Haloperidol Induced Catatonia by Enhancing the Striatum
Dopaminergic Neurotransmission

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